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This epigenetic heterogeneity, both between intertumor and intratumor, is a hallmark of human cancers and is increasingly recognized as a critical driver of resistance to cancer therapies

Mol Cell 18:379391 Sobajima T, Kowalczyk KM, Skylakakis S, Hayward D, Fulcher LJ, Neary C, Batley C, Kurlekar S, Roberts E, Gruneberg U et al (2023) PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size